王聪,张晓梅,王淑芳,赵义名,赵丽,聂燕,张银亮,郭亮亮,孙刚.海南本地人群与“候鸟”人群胃幽门螺杆菌根除方案分析[J].转化医学杂志,2019,8(2):105-109
海南本地人群与“候鸟”人群胃幽门螺杆菌根除方案分析
Analysis of eradication therapy of Helicobacter pylori between Hainan local and migrant patients
  
DOI:
中文关键词:  胃幽门螺杆菌  根除率  疗效分析  海南地区
英文关键词:Helicobacter pylori (H.pylori)  Eradication rate  Efficacy analysis  Hainan area
基金项目:军队转化医学项目(2016TM-035);海南省重点研发计划(ZDYF2017094)
作者单位
王聪 解放军总医院第一医学中心消化内科 
张晓梅 解放军总医院第一医学中心消化内科 
王淑芳 解放军总医院第一医学中心消化内科 
赵义名 解放军总医院海南医院消化内科 
赵丽 解放军总医院海南医院消化内科 
聂燕 解放军总医院海南医院消化内科 
张银亮 解放军总医院海南医院消化内科 
郭亮亮 解放军总医院海南医院消化内科 
孙刚 解放军总医院第一医学中心消化内科 
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中文摘要:
      目的 对比分析海南本地人群与外地“候鸟”人群胃幽门螺杆菌(Helicobacter pylori,H.pylori)根除方案、疗效差异。方法 收集2012年10月—2017年12月在解放军总医院海南医院首次就诊的H.pylori感染患者的临床和随诊资料。共收集到具有完整临床信息和随访资料的患者749例,男性430例(57.4%),女性319例(42.6%),年龄14~70(42.0±12.6)岁。根据来源将患者分为“候鸟”人群组和海南本地人群组。回顾性分析2组患者人群的人口学信息、根除方案、根除效果及治疗规范性差异。结果 H.pylori患者海南本地人群361例(48.2%),“候鸟”人群388例(51.8%);就诊患者年龄海南本地人群(40.0±12.1)岁小于“候鸟”人群(45±12.8)岁(P<0.05),海南本地人群中女性患者就诊率(177/361,49.1%)高于“候鸟”人群女性患者就诊率(142/388,36.6%)(P<0.05);总根治率66.8%。标准方案中含PPI和铋剂的四联方案占74.9%,2组差异比较无统计学意义(P>0.05),其中规范化四联治疗方案中PPI+铋剂+阿莫西林+甲硝唑H.pylori根除率海南本地人群(80.7%)高于“候鸟”人群(67.0%)(P<0.05)。结论 海南本地人群和“候鸟”人群在H.pylori一线治疗的规范化和根除率方面均较低。需进一步分析原因,进一步合理用药并提高当地患者H.pylori根除率。
英文摘要:
      Objective To analyze the eradication therapy of Helicobacter pylori (H.pylori) between Hainan local patients and migrant patients. Methods H.pylori infected patients for the first-line treatment were enrolled in the Hainan Hospital of Chinese PLA General Hospital from October 2012 to December 2017. A total of 749 patients (430 for male and 319 for female) with the age of 42 years old were enrolled in this study. According to resident information, patients were divided into “migrant” and Hainan local population. In this retrospective study, the clinical and follow-up data of the two groups were analyzed. Results There were 361 cases (48.2%) for Hainan local patients and 388 cases (51.8%) for migrant patients. The age of in Hainan local patients (40.0±12.1) was younger than that in migrant group (45±12.8) (P<0.05). The rate of female patients in Hainan local group (177/361, 49.1%) was higher than that in migrant group (142/388, 36.6%) (P<0.05). The overall eradication rate was 66.8%. Rate of PPI/Bismuth-based quadruple regimen was 74.9%. The eradication rate of PPI/Bismuth/Amoxicillin/Metronidazole in Hainan local population (80.7%) was higher than that in migrant group (67.0%) (P<0.05). Conclusion The standard first line treatment rate and eradication rate of H.pylori didn’t reach the acceptable level in both Hainan local patients and migrant patients. Affecting factors should be investigated to improve H.pylori eradication rate.
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