邱博芸,章阳.血清PCT、NLR及BUN水平与急性胰腺炎严重程度的相关性分析[J].转化医学杂志,2020,9(4):226-229
血清PCT、NLR及BUN水平与急性胰腺炎严重程度的相关性分析
Correlation between serum PCT, NLR and BUN levels and severity of acute pancreatitis
  
DOI:
中文关键词:  急性胰腺炎  降钙素原  中性粒细胞与淋巴细胞比值  尿素氮
英文关键词:Acute pancreatitis (AP)  Procalcitonin (PCT)  Neutrophil lymphocyte ratio (NLR)  Blood urea nitrogen (BUN)
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作者单位
邱博芸 成都医学院第二附属医院(核工业四一六医院)消化内科 
章阳 成都医学院第二附属医院(核工业四一六医院)消化内科 
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中文摘要:
      目的探讨急性胰腺炎(acute pancreatitis,AP)患者血清降钙素原(procalcitonin,PCT)、中性粒细胞与淋巴细胞比值(neutrophil lymphocyte ratio,NLR)以及尿素氮(blood urea nitrogen,BUN)水平与疾病严重程度的关系。方法收集2014年3月—2018年5月在成都医学院第二附属医院就诊的148例AP患者。所有病例均在入院后完善血生化检查,将患者按照2012亚特兰大分类标准分为轻度急性胰腺炎(mild acute pancreatitis,MAP)、中度急性胰腺炎(moderately severe acute pancreatitis,MSAP)、重度急性胰腺炎(severe acute pancreatitis,SAP)3组。比较3组患者入院后第1天清晨血清PCT、NLR及BUN水平,使用受试者工作特征(receiver operating characteristic,ROC)曲线评价血清PCT、NLR及BUN水平预测轻度、中度、重度AP的效力。使用Ranson评分对患者进行病情评估。结果SAP组血清PCT、NLR、BUN水平及Ranson评分高于MAP组、MSAP组,且MSAP组上述指标高于MAP组,差异比较具有统计学意义(P<0.05);SAP组住院天数多于MAP组、MSAP组,MSAP组住院天数多于MAP组(P<0.05);Pearson相关分析结果显示血清PCT、NLR、BUN水平均与Ranson评分得分显著正相关((r=0.48,P<0.05;r=0.62,P<0.05;r=0.40,P<0.05);ROC曲线分析表明PCT、NLR、BUN 3者联合评估轻度、中度、重度AP的AUC分别大于PCT和BUN单项(P<0.05),与NLR差异比较无统计学意义(P>0.05)。结论血清PCT、NLR、BUN水平均与AP病情严重程度呈正相关,且对轻度、中度、重度AP预测具有一定价值,3者联合应用对评估AP病情严重程度具有较好的早期预测价值。
英文摘要:
      ObjectiveTo explore relationship between serum procalcitonin (PCT), neutrophil lymphocyte ratio (NLR), blood urea nitrogen (BUN) levels and severity of disease in patients with acute pancreatitis (AP). MethodsOne hundred and forty eight AP patients who were treated in the hospital from March 2014 to May 2018 were enrolled. The blood biochemical examination was completed on all patients after admission. According to Atlanta classification criteria in 2012, they were divided mild acute pancreatitis (MAP), moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP). On the first day in the morning after admission, levels of serum PCT, NLR and BUN were compared among the three groups. The efficiency of PCT, NLR and BUN levels for predicting mild, moderate and severe AP was evaluated by receiver operating characteristic (ROC) curves. Ranson score was used to evaluate the patient’s condition. ResultsThe levels of PCT, NLR and BUN, and Ranson scores in SAP group were higher than those in MAP group and MSAP group. The above indexes in MSAP group were higher than those in MAP group (P<0.05). The hospital stay in SAP group was more than that in MAP group and MSAP group. The hospital stay in MSAP group was longer than that in MAP group (P<0.05). The results of Pearson correlation analysis showed that serum PCT, NLR and BUN levels were significantly positively correlated with Ranson score (r=0.48,P<0.05;r=0.62,P<0.05;r=0.40,P<0.05). ROC curves analysis showed that AUC of PCT, NLR and BUN for assessing mild, moderate and severe AP were larger than those of PCT and BUN alone (P<0.05), without significant difference compared with that of NLR (P>0.05). ConclusionSerum PCT, NLR and BUN levels are positively correlated with AP severity, which are of certain prediction value for mild, moderate and severe AP. The combination of the three is of good early predictive value for assessing AP severity.
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