方庭正,张学林,刘长庭.航天飞行和模拟微重力下微生物次级代谢研究与太空微生物制药[J].转化医学杂志,2020,9(6):388-391
航天飞行和模拟微重力下微生物次级代谢研究与太空微生物制药
Space microbial pharmaceutics and study of microorganism secondary metabolism in spaceflight and simulated microgravity
  
DOI:
中文关键词:  航天飞行  模拟微重力  微生物  次级代谢  微生物制药
英文关键词:Spaceflight  Simulated microgravity  Microorganism  Secondary metabolism  Microbial pharmaceutical
基金项目:国家自然科学基金青年科学基金项目(81600011);中国博士后科学基金面上项目(2016M592928)
作者单位
方庭正 中国人民解放军总医院第六医学中心干部病房呼吸科 
张学林 中国人民解放军总医院第一医学中心高压氧科 
刘长庭 中国人民解放总医院第二医学中心呼吸科 
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中文摘要:
      随着人类对宇宙的不断探索,大量研究观察到微生物次级代谢在航天飞行中的变化,为人类利用太空环境进行高产和高质量微生物制药带来了希望。研究者认为,太空环境下微生物生长停滞期缩短,更早进入生长期,更早产生次级代谢产物。由于空间飞行的稀缺性和高昂成本,研究者利用微重力模拟设备进行微生物次级代谢研究。目前,不同的航天飞行和模拟微重力下微生物次级代谢研究并未观察到趋势相对一致的结果,其表型变化背后的分子生物学机制也有待进一步研究。太空微生物制药利用太空诱变筛选具有商业和医学价值的制药微生物菌株,这种航天飞行后地面筛选的模式具有无法控制诱变方向、被动筛选的缺陷,有待相关诱变通路进一步研究后予以改进。
英文摘要:
      With the exploration of universe, a large number of studies have observed the changes of microbial secondary metabolism in space flight, which provided hope for high yield and high quality microbial pharmaceuticals in the space environment. The researchers believed that microbes in space had a shorter stasis period, which allowed them to enter earlier the growth phase and produce secondary metabolites. Because of the scarcity and high cost of space flight, researchers have also used microgravity simulations to study microbial secondary metabolism. At present, studies on microbial secondary metabolism under different spaceflight and simulated microgravity have not observed relatively consistent results, and the molecular biological mechanism behind the phenotypic changes also needs to be further studied. Microbial pharmaceutical has screened microbial strains with business and medical value the space mutagenesis effect. However, this model of post-flight ground screening was unable to control the mutagenesis direction, defect of passive screeuing which needed to be improved after further studies on relevant mutagenesis pathways.
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