张丽娟,王 真,王永泉.整脊疗法联合针刺放血治疗躁狂症的疗效及对椎-基底动脉流速及神经递质水平的影响[J].转化医学杂志,2021,10(6):374-377
整脊疗法联合针刺放血治疗躁狂症的疗效及对椎-基底动脉流速及神经递质水平的影响
The curative effect of chiropractic combined with acupuncture and bloodletting therapies in the treatment of mania and its influence on vertebral-basal artery flow velocity and neurotransmitter levels
  
DOI:
中文关键词:  躁狂症  针刺放血  整脊  神经递质  椎-基底动脉
英文关键词:Mania  Acupuncture and bloodletting  Chiropractic  Neurotransmitter  Vertebrobasilar artery
基金项目:
作者单位
张丽娟 山东中医药大学针灸推拿学院 
王 真 山东中医药大学针灸推拿学院 
王永泉 山东中医药大学附属医院推拿科 
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中文摘要:
      目的 观察整脊疗法联合针刺放血治疗躁狂症的疗效及对椎-基底动脉流速及神经递质水平的影响。 方法 纳入山东中医药大学附属医院推拿科2018年9月-2020年9月72例躁狂症患者,采用随机数字表法将患者分为观察组和对照组,每组患者36例。对照组患者予以针刺+放血治疗;观察组给予针刺+放血+整脊疗法治疗。比较两组患者治疗前、治疗4周后临床疗效,记录Bech-Rafaelsen 躁狂量表(Bech-Rafaelsen mania rating scale,BMRS)评分、临床疗效总评量表-病情严重度(clinical global impression-severity of illness scale,CGI-SI)评分、椎动脉及基底动脉(VA、BA)的血液流速(Vp、Vm、Vd)、及神经递质5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平。 结果 治疗4周后,两组患者BMRS、CGI-SI评分均较治疗前降低,且观察组低于对照组(P<0.05);观察组的血液流速较治疗前降低,对照组无明显变化,观察组低于对照组(P<0.05;两组5-HT、DA、NE水平降低,且观察组低于对照组(P<0.05)。 结论 针刺放血联合整脊疗法对躁狂症患者的疗效显著,可降低椎-基底动脉的流速及5-HT、DA、NE水平,值得临床推广。
英文摘要:
      Objective To observe the efficacy of chiropractic therapy combined with acupuncture and bloodletting in the treatment of mania and its effect on vertebrobasilar artery flow rate and neurotransmitter level. Methods A total of 72 patients with mania in our hospital from September 2018 to September 2020 were included and randomly divided into observation group and control group (36 cases in each group) by random number table method. The control group was treated with acupuncture + bloodletting, and the observation group was treated with acupuncture + bloodletting + chiropractic therapy. Clinical efficacy was compared between the two groups before treatment and 4 weeks after treatment. Manic score Scale (BMRS), CGI-SI score, blood flow rate (Vp, Vm, Vd) of vertebral artery and basilar artery (VA, BA), neurotransmitters 5-HT, dopamine (DA) and norepinephrine (NE) were recorded. Results After 4 weeks of treatment, BMRS and CGI-SI scores in 2 groups were lower than before treatment, and observation group was lower than control group (P<0.05). The blood flow rate in the observation group was lower than that before treatment, but the control group had no significant change (P<0.05). The levels of 5-HT, DA and NE in the observation group were lower than those in the control group (P<0.05). Conclusion Acupuncture and bloodletting combined with chiropractic therapy has a significant better therapeutic effect on patients with mania, and can reduce vertebrobasilar artery flow rate and 5-HT, DA and NE levels, which is worthy of clinical promotion.
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