林 川,李维玲,张 静,游 昕.支气管动脉介入栓塞序贯灌注化疗对晚期NSCLS患者的疗效及对其NLR、HIF-1α及VEGF等指标的影响评估[J].转化医学杂志,2021,10(6):382-385
支气管动脉介入栓塞序贯灌注化疗对晚期NSCLS患者的疗效及对其NLR、HIF-1α及VEGF等指标的影响评估
Evaluation of the effect of bronchial artery interventional embolization and sequential perfusion chemotherapy on prognosis、NLR、HIF-1 and VEGF in patients with advanced NSCLC
  
DOI:
中文关键词:  支气管动脉介入栓塞  非小细胞肺癌  化疗  疗效  预后
英文关键词:Interventional embolization of bronchial artery  Non-small cell lung cancer  Chemotherapy  Curative effect  prognosis
基金项目:
作者单位
林 川 宜宾市第一人民医院肿瘤科 
李维玲 宜宾市第二人民医院肿瘤科 
张 静 宜宾市第二人民医院肿瘤科 
游 昕 四川大学华西医院肿瘤科 
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中文摘要:
      目的 探讨支气管动脉介入栓塞序贯灌注化疗对晚期非小细胞肺癌(non small cell lung cancer ,NSCLC)患者的疗效及对其NLR、HIF-1α及VEGF等指标的影响。方法 选取宜宾市第一人民医院和华西医院收治的85例NSCLC患者作为研究对象。根据治疗方式的差异将其分为两组。其中研究组患者40例,采用支气管动脉介入栓塞序贯灌注化疗治疗,对照组患者45例,采用常规化疗药物治疗,比较两组患者的临床疗效等差异。结果 治疗前两组患者的肿瘤直径比较差异无统计学意义(P>0.05),而治疗后研究组肿瘤直径小于对照组(P<0.05);治疗后3个月,研究组的客观缓解率(72.5%)高于对照组(42.2%)(P<0.05);治疗前两组患者的HIF-1α、VEGF、NLR比较差异无统计学意义(P>0.05),而治疗后研究组HIF-1α、VEGF、NLR均比对照组改善明显(P<0.05);治疗后,研究组患者的并发症发生率(15%)低于对照组(35.6%)(P<0.05);治疗后一年,研究组的生存率高于对照组(P<0.05)。结论 支气管动脉介入栓塞序贯灌注化疗对晚期NSCLS患者的疗效更为显著,同时可降低肿瘤相关指标水平及化疗相关并发症发生率,最终改善其预后,值得临床推广应用。
英文摘要:
      Objective To investigate the effect of bronchial artery interventional embolization and sequential perfusion chemotherapy on prognosis、 NLR、HIF-1 and VEGF in patients with advanced NSCLC. Methods 85 cases of NSCLC patients in Yibin City First People's Hospital were selected as the research objects. They were divided into two groups according to the different treatment methods. Among them, 40 patients in the study group were treated with bronchial artery interventional embolization sequential perfusion chemotherapy, while 45 patients in the control group were treated with conventional chemotherapy drugs. The clinical efficacy of the two groups were compared. Results Before treatment, there was no difference in tumor size between the two groups (P>0.05), but three months after treatment, the tumor size of the study group were significantly smaller than that of in the control group (P<0.05); After treatment, the objective remission rate of the study group was significantly higher than that of in the control group (P<0.05). Before treatment, there was no difference in the related test indexes between the two groups (P>0.05), but after treatment, the related test indexes of the study group were significantly improved than those of in the control group (P<0.05). After treatment, the incidence of complications in the study group was significantly lower than that of in the control group (P<0.05). One year after treatment, the survival rate of the study group was significantly higher than that of in the control group (P<0.05). Conclusion Bronchial artery interventional embolization sequential infusion chemotherapy has better therapeutic effect on patients with advanced NSCLC, and can reduce the level of tumor related indicators and the incidence of chemotherapy-related complications, and ultimately improve the prognosis of patients, which is worthy of clinical application.
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