徐文琦,唐晓琦.不同病毒载量乙型肝炎患者的肝功能与肠道微生态分布及数量变化的关系研究[J].转化医学杂志,2022,11(5):287-291
不同病毒载量乙型肝炎患者的肝功能与肠道微生态分布及数量变化的关系研究
Study on the Relationships between hepatitis B virus load and Liver Function, Intestinal Microflora in Hepatitis B Patients
  
DOI:
中文关键词:  高病毒载量乙型肝炎  肝功能  肠道微生态
英文关键词:Hepatitis B patients with high viral load  Liver function  Intestinal microflora
基金项目:
作者单位
徐文琦 宜兴市人民医院感染科 
唐晓琦 宜兴市人民医院感染科 
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中文摘要:
      目的 分析不同病毒载量乙型肝炎患者的肝功能与肠道微生态分布及数量变化的关系。方法 选择2017年1月-2021年1月经宜兴市人民医院治疗的乙型肝炎患者94例为研究对象,根据乙型肝炎病毒(HBV)-DNA检测结果将患者分为阴性组29例,阳性组患者共65例。按照HBV-DNA载量将患者分为低、中拷贝组43例、高拷贝组22例,同期选择50例正常者为对照组。比较各组肝功能指标及与肠道微生物数量变化,分析高病毒载量乙型肝炎患者的肝功能与肠道微生态的关系。结果 阳性组患者丙氨酸氨基转移酶(alanine aminotransferase, ALT)和天冬氨酸氨基转移酶(aspartate aminotransferase, AST)、γ-谷氨酰转肽酶(γ-glutamyl transpeptidase, γ-GT)水平均高于阴性组、对照组(P<0.05)。低、中拷贝组和高拷贝组患者ALP、γ-GT水平比较无显著差异(P>0.05)。高拷贝组患者ALT、AST水平均高于低、中拷贝组(P<0.05)。阳性组患者普雷沃氏菌属、梭菌属、肠杆菌科细菌、粪球菌属、白色念珠菌数量均高于阴性组、对照组(P<0.05),而拟杆菌属、瘤胃球菌属、乳酸杆菌属、双歧杆菌属低于阴性组、对照组(P<0.05)。高拷贝组患者普雷沃氏菌属、瘤胃球菌属、梭菌属、粪球菌属、白色念珠菌数量均高于低、中拷贝组(P<0.05),而拟杆菌属低于低、中拷贝组(P<0.05)。高病毒载量乙肝患者ALT、AST、γ-GT水平与拟杆菌属、瘤胃球菌属、乳酸杆菌属呈负相关,与普雷沃氏菌属、梭菌属、双歧杆菌属、粪球菌属、白色念珠菌、肠杆菌科细菌呈正相关(P<0.05)。结论 高病毒载量乙肝患者肝功能与肠道微生态变化呈相关性。其患者病毒载越高,肠道微生态越紊乱,导致肝功能受损,影响肝功能指标水平变化。
英文摘要:
      Objective To investigate the relationships between hepatitis B virus load and liver function, intestinal microflora in hepatitis B patients. Methods A total of 94 patients with hepatitis B treated in our hospital from January 2017 to January 2021 were selected as the study subjects. According to the results of hepatitis B virus (HBV) - DNA detection, the patients were divided into negative group (29 cases) and positive group (65 cases). According to the HBV DNA load, the HBV positive patients were divided into lowmedium copy group (43 cases) and high copy group (22 cases). At the same time, 50 normal persons were selected as control group. Then the relationships between hepatitis B virus load and liver function, ,intestinal microbial were analyzed. Results The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ- Glutamyl transpeptidase (γ- GT) were higher than these in the negative group and control group (P<0.05). For ALP γ-GT, there was no difference between the low-median copy group and high copy group (P>0.05). T levels of he ALT and AST in the high copy group were higher than these in the low middle copy group (P<0.05). The levels of Prevotella, Clostridium, Enterobacteriaceae, Fecal coccus, and Candida albicans in the positive group were higher than these in the negative group and control group (P<0.05), while the levels of Bacteroides, Ruminococcus, Lactobacillus, and Bifidobacterium were lower than these in the negative group and control group (P<0.05). The levels of Prevotella, Ruminococcus, Clostridium, Fecal coccus, and Candida albicans in the high copy group was higher than these in the low-middle copy group (P<0.05), while level of Bacteroides was lower than that in the low-middle copy group (P<0.05).The levels of ALT, AST, and γ-GT were negatively correlated with Bacaeroides, Rumenococcus, and Lactobacillus, and positively correlated with Prevotella, Clostridium, Bifidobacterium, Coprococcus, Candida albicans, and Enterobacteriaceae bacteria (P<0.05). Conclusion Liver function is correlated with intestinal microflora in hepatitis B patients with high viral load, and the increased viral load of the patient leads the imbalance of intestinal microflora and thus resulted the liver function damage.
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