| 肖飞.转化医学是实现精准医学的必由之路——思考精准医学、循证医学及转化医学之间的协同关系[J].转化医学杂志,2015,4(5):257-260 |
| 转化医学是实现精准医学的必由之路——思考精准医学、循证医学及转化医学之间的协同关系 |
| Translational medicine is the only pathfinder for realization of precision medicine--exploit the synergy of precision medicine, translational medicine and evidence based medicine |
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| 中文关键词: |
| 英文关键词:Precision medicine Evidence based medicine Translational medicine Disease classification Big data infoport Cure Disease staging Evaluation of disease activity Iatrogenic gene mutation |
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| 英文摘要: |
| Since entering of 21st Century, two paradigm shifts have been achieved in medical science. The first is the birth of translational medicine, and the second is precision medicine. The translational medicine improves the collaborations among the basic scientist, clinician, academy and pharmaceutical enterprise, which pushes forward translations from basic scientific discovery to clinical application. However, focusing on regulatory approval as only goal and criteria, the effect of translational medicine practice was far from satisfactory, and effective rate of most products are less than 50% in real world. Besides failure to bring in true values to patients, some new translated products add extra burden to the society, and in this case, the major beneficiary is pharmaceutical companies. It is not surprised that the conclusions generated by clinical studies tends to be obscure, and sometimes, even misleading if the translational studies are based on inaccurate diagnostic criteria, arbitrated disease staging and evaluation system. It is time to reconsider the rational goal of translational medicine. Instead of targeting at regulatory approval only, we should redefine the disease based on its molecular driver and underline mechanism. A new classification of disease needs to be developed by building a knowledge network for biomedical Research. Through multidisciplinary collaborations, the precision medicine, i.e. precise prevention， precise diagnosis, precise staging and precise evaluation of disease is pursued. Therefore, precision medicine is the ultimate goal of translational medicine, evidence based medicine is the tool for practice of translational medicine, and translational medicine is the pathfinder for realization of precision medicine. |
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